A monochrome color scheme for websites typically involves using shades of a single color, often black, white, or gray. This design choice can create a minimalist and sleek aesthetic, which is often favored for its simplicity and readability. Monochrome schemes are also practical for accessibility, as they allow users with color vision deficiencies to distinguish between elements. However, designers must consider the contrast and readability of text and other elements to ensure a user-friendly experience.