Color combination in design and aesthetics can greatly affect the visual appeal of a picture. The 'best-looking' color combinations often depend on personal preference and the context in which the colors are used. However, popular color palettes that are often praised for their aesthetic appeal include monochromatic schemes (using different shades of a single color), complementary color schemes (using colors opposite each other on the color wheel), and analogous color schemes (using colors next to each other on the color wheel). These combinations are often chosen for their harmony and balance. For specific color combinations, one might look at palettes like the Monet palette (soft blues and greens), the Picasso palette (vivid reds and blues), or the Earth palette (natural earth tones).