The five best color combinations often depend on personal preference and the context in which they are used. However, popular combinations include: 1. Black and white, a classic pairing that creates a sleek and timeless look. 2. Blue and orange, a complementary scheme that provides high contrast and energy. 3. Green and brown, a natural combination that evokes a sense of harmony and grounding. 4. Pink and gray, a soft and modern combination that is versatile and soothing. 5. Yellow and purple, a vibrant and playful combination that stands out and is full of personality.