The best color for an xlsx file can vary based on personal preference and the context in which the file is used. However, some popular choices include shades of blue, gray, or green, which are considered professional and easy on the eyes. To change the color of a workbook in Excel, go to the 'Design' tab, click on 'Page Setup,' and then choose 'Colors.' From there, you can select from various pre-set themes or create a custom color scheme.