The best-looking two-color combination refers to the most aesthetically pleasing pair of colors that work well together. This can vary greatly depending on personal taste, cultural influences, and the context in which the colors are used. In design, color theory provides guidelines for creating harmonious color schemes, such as complementary colors, analogous colors, and split-complementary colors. To determine the best-looking two-color combination, one might consider the emotional response, cultural significance, and visual harmony of the colors.