In Adobe InDesign, creating a two-color gradient involves selecting two colors and applying them to a gradient fill in an object. To do this, go to the 'Swatches' panel, select the two colors you want to use, and then click on the 'Gradient' tool. Draw a gradient shape over the object where you want the gradient to appear. You can adjust the gradient's direction and midpoint in the 'Object Styles' panel or using the 'Gradient Tool Options' dialog box.