To create a gradient with two colors, you can use various graphic design software or programming libraries. In graphic design software like Adobe Photoshop or GIMP, you can select the gradient tool and choose a two-color gradient from the options. In programming, libraries like PIL (Python Imaging Library) or ImageMagick allow you to create gradients using code. Typically, you specify the start and end colors and the type of gradient (linear, radial, etc.) to achieve the desired effect.