To transform three distinct colors into a gradient, you can use various graphic design software like Adobe Photoshop or Illustrator. In these programs, you can create a gradient by selecting the gradient tool and choosing the three colors you want to blend. You can adjust the gradient type (linear, radial, angle, reflected, or diamond) and the gradient sliders to control the transition between the colors. This technique is commonly used in web design, graphic design, and digital art to create smooth, visually appealing transitions between colors.