The best color palette with red for design typically involves choosing shades of red that complement each other and enhance the overall aesthetic. Red is a powerful color that can evoke emotions like passion, energy, or danger. When used in design, it is important to balance red with complementary colors to avoid overwhelming the viewer. Common complementary colors for red include green, purple, and orange. Designers often use tools like Adobe Color or Coolors to generate color palettes that include red, ensuring harmonious and visually appealing combinations.